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PATHd8 is implemented in the C-program PATHd8 and is freely available from this website.
(The time-complexity is O(n*t), where n is the number of nodes and t is the number of time contraints.) Input is given as a phylogenetic tree with branch lengths.
The output also contains results from the MPL analysis described in Britton et al.
(2002), which can be of interest when there are no fossil datings or if the clock hypothesis is of interest (a clock test is performed at each node).